Treatment of early and established Cryptococcus neoformans infection with 1 radiolabeled antibodies in immunocompetent mice
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Running title: RIT of C. neoformans in immunocompetent mice 3 4 Zewei Jiang 1 , Ruth A. Bryan 1 , Alfred Morgenstern 2 , Frank Bruchertseifer 2 , Arturo 5 Casadevall 3,4 , Ekaterina Dadachova 1,3* 6 Departments of 1 Nuclear Medicine, 3 Microbiology and Immunology and 4 Medicine, Albert 7 Einstein College of Medicine, Bronx, NY, USA; 2 European Commission, Joint Research 8 Centre, Institute for Transuranium Elements, Karlsruhe, Germany 9 10 *Author for correspondence: Ekaterina Dadachova, PhD, Albert Einstein College of Medicine, 11 Department of Nuclear Medicine, 1695A Eastchester Rd., Bronx, NY 10461; Ph: 718-40512 8485; FAX: 718-4058457; E-mail: [email protected] 13 14 15 Word count: abstract – 50, text 1,000. 16 17 18 19 20 21 22 23 Copyright © 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00473-11 AAC Accepts, published online ahead of print on 17 October 2011
منابع مشابه
Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice.
We investigated the utility of radioimmunotherapy (RIT) in early and established cryptococcal infection in immunocompetent mice. RIT with (213)Bi-18B7 antibody completely eliminated fungus from mouse lungs and brains for early infection, while (188)Re-18B7 significantly reduced CFU in the lungs or both lungs and brains during early and established infection, respectively. The results point to t...
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تاریخ انتشار 2011